Pitfalls of liver stiffness measurement: a 5-year prospective study of 13, examinations. Louvet A, Mathurin P. Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat Rev Gastroenterol Hepatol. Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease.
World J Gastroenterol. Utility of a new model to diagnose an alcohol basis for steatohepatitis. Drug-induced liver injury. Mayo Clin Proc. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. Serum alanine aminotransferase elevation during 10 days of acetaminophen use in nondrinkers. Drug-related hepatotoxicity. N Engl J Med. Food and Drug Administration. FDA drug safety communication: important safety label changes to cholesterol-lowering statin drugs.
February 28, Accessed March 24, Centers for Disease Control and Prevention. Surveillance for viral hepatitis—United States, Updated June 22, Accessed August 6, Preventive Services Task Force. Hepatitis C: screening. June Hepatitis B virus infection: screening, May Diagnosis and management of hemochromatosis: practice guideline by the American Association for the Study of Liver Diseases.
Hereditary hemochromatosis. Screening for hemochromatosis. Clinical practice. Alpha 1 -antitrypsin deficiency. Bals R. Alphaantitrypsin deficiency. Best Pract Res Clin Gastroenterol. Teckman JH, Jain A. Advances in alphaantitrypsin deficiency liver disease. Curr Gastroenterol Rep.
Diagnosis and management of autoimmune hepatitis. Krawitt EL. Autoimmune hepatitis. Evaluation of abnormal liver-enzyme results in asymptomatic patients. European Association for the Study of the Liver. EASL clinical practice guidelines: Wilson's disease. Health Technol Assess. Giboney PT. Mildly elevated liver transaminase levels in the asymptomatic patient [published correction appears in Am Fam Physician.
Johnston DE. Special considerations in interpreting liver function tests. This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.
Contact afpserv aafp. Want to use this article elsewhere? Get Permissions. Read the Issue. Sign Up Now. Next: Hoarseness in Adults. Dec 1, Issue. Author disclosure: No relevant financial affiliations.
C 10 Repeat liver enzyme testing is not necessary in the initial workup for elevated transaminase levels. B 43 Lifestyle modifications with follow-up are appropriate if history, physical examination, and workup suggest nonalcoholic fatty liver disease. B 4 — 6 , 10 , 11 , 43 If the history and physical examination are unrevealing, clinicians should initiate a stepwise epidemiologic approach to diagnosing the cause of elevated transaminase levels. Enlarge Print Table 1. Table 1.
Enlarge Print Table 2. Table 2. Enlarge Print Table 3. Table 3. Enlarge Print Table 4. Table 4. Read the full article. Get immediate access, anytime, anywhere.
This content does not have an English version. This content does not have an Arabic version. See more conditions. Request Appointment. Symptoms Elevated liver enzymes. Sections Basics Definition Causes When to see a doctor. Definition Causes When to see a doctor. Products and services. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information.
Please try again. Something went wrong on our side, please try again. Show references Friedman LS. See related article on mildly elevated liver transaminase levels. The liver releases several substances when it is injured.
About three out of 10 people will have normal levels again if blood tests are repeated in two to four weeks. Medical conditions such as hepatitis swelling of the liver , nonalcoholic fatty liver disease, the metabolic syndrome, and alcoholic liver disease are the more common causes. Certain medicines can also cause elevated liver enzymes. Your doctor will ask you questions and examine you to try to find out why your enzymes are elevated. He or she may do another blood test to make sure the results weren't wrong.
If these tests are also positive, your doctor will do other tests to find out what is causing the problem. Treatment depends on what is causing your liver enzymes to be elevated. If your doctor thinks you have nonalcoholic fatty liver disease or the metabolic syndrome, you will need to watch your diet, stop drinking alcohol, lose weight, and control your cholesterol. If your liver enzymes are still elevated after six months, your doctor may do more blood tests or an ultrasound.
He or she also might want you to see another doctor who specializes in the digestive system. This doctor will check for other causes and may also do a liver biopsy. Already a member or subscriber? Log in. Interested in AAFP membership?
0コメント